Human as the manifestation of God's creature, according to His guidance, has an obligation to bring mercy (benefit) to the entire universe including to the fellow human beings. One of the blessings of human perfection among God’s creatures is intellectual. "Go Green" is a term originated from Thoreau's inspiration through his book entitled The Maine Woods (1864) which has been experiencing scientific evolution in various themes of "Green" until in this era of the Industrial Revolution 4.0. Using qualitative phenomenological study by employing Interactive Model analysis tools, this study aims to answer the focus of the problem of the existence of "Go Green" as a basis for thinking and developing science and its implementation in the era of the Industrial Revolution 4.0. Based on the findings, it can be concluded that humans in the "Industrial Revolution 4.0" era with their intellectuals are able to realize "Go Green" through the implementation policy criteria related to pollution prevention, product stewardship, clean technology, environmental performance, competitive benefits integrated with Internet of Things and Services (IoT and IoS) into Cyber Physical System (CPS) to build Smart Factory. The findings of a depth analysis of the correlation with the Qur'an and Sunnah showed the harmony with the guidance of Islam. The shift in polluted egoistic values is at the end proven to be eliminated by the realization of feminine values. Thus, the existence of "Go Green" in the Industrial Revolution 4.0 era is the right theme to bring and realize the mercy for fellow human beings and the entire universe