Cadmium toxicity is a pervasive environment problem prevalent throughout the world. Cadmium is notorious for its toxicity due to its nature of extreme solubility and mobility through food chain. Cadmium strongly absorbs into ecosystems and carried through food web and leads to bioaccumulation. As it is high toxic potential in mammals, it leads to destruction of homeostasis. The contamination of water by metal compounds is a worldwide environmental problem (Nriaguetal,1988,). It has been reported that low-dose exposure for prolonged period to Cadmium leads to hypertension and also arteriosclerosis without renal dysfunction in rats and rabbits [Perry and Erlanger 1974; Subramanyam et al 1992]. Experiments were carried out in rabbits to determine the effects of prolonged treatment of cadmium on histopathological changes and biochemical alterations of lipid profiles in various tissues and serum compared to normal rabbits. The cadmium induced oxidative stress leads to the tissue destruction by the elevated free radicals by suppression of antioxidant scavenger system. Cadmium toxicity is a novel risk factor, and here in, we discuss the toxicological impact on oxidizing agents, biochemical status regarding the tissues in female rabbits. It is postulated that atherosclerotic changes in rabbits probably occurred through toxic effects of cadmium but the exact mechanism needs to be elucidated.